According to the World Health Organization (WHO), one of the top 10 threats to public health in the world, Superbug is shortly after Australian researchers have developed new ways to eradicate antibiotic-resistant strains. It can be a thing.
Researchers at Monash University in Victoria have destroyed superbags, prevented antibiotic resistance, reduced antibiotic intake, and restricted untargeted bacteria from contacting drugs to develop resistance. I found a new way to do it.
“This is an amazing discovery of how we deliver medicines and how the medicines we take will affect us in the future.” Dr. Hsin-Hui Shen, Principal Researcher of the project, said: Of the Faculty of Materials Science and Engineering, Monash University.
Researchers’ new therapies kill superbugs using antibiotics that have not yet developed high resistance to the combination with nanoparticles.
The method developed by the University Institute for Biomedical Discovery and Professor Shen and Jian Li of the Faculty of Microbiology is antibacterial using cubicomes that destroy the outer membrane of bugs using water-resistant nanoparticles loaded with superbug antibiotics. Use a polytherapy-based approach to combat resistance.
“Nanoparticles have long been used specifically as antimicrobial carriers, but the use of nanoparticles in multidrug therapy with antibiotics to overcome antimicrobial resistance has been overlooked,” Shen said. I am saying.
“The combination therapy of nanoparticles and antibiotics can reduce the dose intake of the human body and overcome multidrug resistance.”
The new method involves a two-step process. The first step is to use an antibiotic like polymyxin to destroy the outer membrane of the super bug. Superbug’s unique outer membrane is a characteristic that gives them resistance, and while the membrane has a slime coating, its best protection is unique, preventing most antibiotics from invading and killing bugs. It is a molecule.
Polymyxin is one of the antibiotics that can pass through unique molecules and destroy the cell wall. However, if they are used continuously to treat bacteria, super bugs develop resistance to them.
Therefore, in the second step, nanoparticles such as cubicomes are used to further destroy the outer membrane and destroy the bug. Because the nanoparticles themselves have antibiotic properties, they help reduce the dose of antibiotics used and prevent bugs from developing resistance.
Development takes place after WHO In 2019, we declared antimicrobial resistance one of the top 10 threats to public health in the world.
Antimicrobial resistance is caused by the abuse of antibiotics and other antibiotics, making it increasingly difficult or even impossible to treat infections, and many people die.
According to WHO, most of the antibiotics on the market in recent decades are derivatives of antibiotics found in the 1980s, not new types of antibiotics, but 43 antibiotics currently on the market. All the substances do not adequately deal with super bugs, which means that more and more people will die. Bacteria develop resistance to a limited supply of antibiotics, so basic infections such as pneumonia and urinary tract infections.
“Continuous failures in the development, manufacture and distribution of effective new antibiotics further contribute to the effects of antimicrobial resistance (AMR) and threaten our ability to successfully treat bacterial infections.” Dr. Hanan Bulky, Deputy Director of WHO on Antibacterial Resistance, said.
People undergoing surgery and chemotherapy are at high risk, and the struggle to develop more and more antibiotics is detrimental to the global economy.
This is where new technology is born.
“Once the bacteria become resistant, the original antibiotics can no longer kill the bacteria. Instead of looking for new antibiotics to combat superbags, we use a nanotechnology approach to antibiotics. You can reduce your intake and effectively kill multidrug-resistant bacteria, “Shen said.
The testing phase of the Monash University research project is currently underway.