Findings published from a UK study that intentionally infected participants with COVID-19



Symptoms of COVID-19 develop earlier than most experts thought, according to the first findings of a study that deliberately infected volunteers with the disease.

Participants experienced symptoms on average two days after contact with the CCP (Chinese Communist Party) virus. This causes COVID-19.

Approximately 40 hours after contact, the virus was initially detected using a cotton swab in the throat, the researchers said. Nose detection was performed approximately 58 hours after contact.

Viral load increased rapidly after detection and peaked approximately 6 days after contact with the virus.

Many health agencies around the world, including the US Centers for Disease Control and Prevention, state that symptoms can develop in two days, but also for periods that can last as long as 14 days after being exposed to the disease. Explaining.

Thirty-six participants in this study were between the ages of 18 and 29 and had no evidence of previous infection or vaccination.

Half were infected and all but two showed symptoms.

Symptoms included loss of smell that remained in the three participants after 90 days.

No serious adverse events were recorded and no lung problems were detected.

Participants were deliberately infected, but were infected with the amount of virus described as the “lowest possible dose” that caused the infection. The amount was about the same as that seen in the nasal drops when the volunteers reached their peak viral load. The virus was wild-type and pre-alpha.

The Human Challenge Trial was conducted at the Royal Free Hospital in London with government support by British researchers, including researchers at Imperial College London.

Results were published as a preprint or prior to peer review. ResearchGate website..

“Our study reveals some very interesting clinical insights, especially regarding the short incubation period of the virus, very high viral shedding from the nose, and the usefulness of immunochromatography that has potential impacts on public health. “I am doing it,” said a statement at the Institute of Infectious Diseases, Professor Christopher Chiu Imperial College London.

“This trial already provides some compelling new insights into SARS-CoV2 infection, but perhaps its greatest contribution is to study the infection and its immune response in detail, as well as new vaccines and treatments. Is to open up new ways to help test the disease, “added Dr. Michael Jacobs, an infectious disease consultant at the Royal Free London NHS Foundation Trust, one of our collaborators.

SARS-CoV-2 is another name for the CCP virus.

Lawrence Young, a virologist and professor of molecular oncology at Warwick Medical School, who was not involved in the study, said a groundbreaking study “before natural infections confirming the rapid onset of upper respiratory tract infections two days later. Reinforces observations from the study, but high levels of the virus are produced in the throat before it is detected in the nose. “