Recent discoveries by Japanese scientists are reported to open up new drug possibilities that can help regenerate what has been lost. tooth In humans. Researchers at Kyoto University and the University of Fukui have found that suppressing the uterine sensitization-related gene-1 (USAG-1) gene using its antibody may lead to efficient tooth growth in animal experiments. I found. The report is Science AdvancesWe noted that the USAG-1 antibody can stimulate tooth growth in mice suffering from a congenital condition known as tooth aplasia. Genetic causes of too many teeth are being investigated as a hint for adult tooth regeneration. In humans, people have more or fewer teeth than the usual 32 teeth due to a congenital disease that affects about 1% of the population. Katsutoshi Takahashi, Senior Lecturer, Graduate School of Medicine, Kyoto University, one of the lead authors of the study, described how their team identified the basic molecules involved in tooth development. “Individual tooth morphogenesis depends on the interaction of several molecules, including BMP, or bone morphogenetic proteins, and Wnt signaling.” He was reported to have said. In addition to tooth development, the study further noted that BMP and Wnt are involved in regulating the growth of multiple organs and tissues in the very early stages of human development. This is why drugs that affect the activity of BMPs and Wnts are avoided due to the side effects they can cause systemically. The findings show for the first time the benefits of monoclonal antibodies- Protein that mimics the immune system To fight off pathogens-shown about tooth regeneration. It provides a new therapeutic framework for clinical problems that have long been limited by implants and other artificial solutions. Research co-author Fukui University Bunkyo Studies Explanation: “Traditional tissue engineering is not suitable for tooth regeneration. Our research shows that cell-free molecular therapy is effective for a wide range of congenital tooth aplasias.” The research team first investigated the effects of several monoclonal antibodies against USAG-1, commonly used to treat cancer, arthritis, and vaccine development. They finally isolated one antibody that was found to interfere with the interaction of USAG-1 and BMP alone. A single dose of this antibody was sufficient to produce an entire tooth. Other experiments have shown similar results with ferrets. Takahashi pointed out that ferrets are gifiodon animals and have a tooth pattern similar to that of humans. Researchers are currently considering testing antibodies in animals such as pigs and dogs. Feature image via movidagrafica
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