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The Daily Beast

Are the side effects of the COVID vaccine a good sign?

Photo: If you have a headache or the weather is a little depressed after getting the Getty COVID-19 vaccine, it’s common to hear something like, “Oh, my immune system is really working.” .. Conversely, if you are unaware of the side effects, you may be worried that your injections may stop working or your immune system may stop responding at all. What you can notice after vaccination and what is happening at the cellular level in your body? Robert Finberg is a physician specializing in infectious diseases and immunology at the University of Massachusetts School of Medicine. He explains how this perception does not match the reality of how vaccines work. What does your body do when you get vaccinated? Your immune system responds to the foreign molecules that make up the vaccine through two different systems. To what is called an innate immune response. The system activates as soon as cells become aware that they have been exposed to a foreign substance, from debris to viruses. Its goal is to eliminate intruders. White blood cells called neutrophils and macrophages migrate to the invaders and destroy them. This first line of defense is relatively short-lived and lasts hours to days. The second line of defense takes days or weeks to get up and run. This is a long-term adaptive immune response. It relies on T and B cells of the immune system to learn to recognize specific invaders, such as coronavirus proteins. If an intruder encounters it again months or years later, it is these immune cells that recognize the old enemy and begin producing antibodies that destroy it. In the case of the SA RS-CoV-2 vaccine, it takes about 2 weeks to develop an adaptive response that provides long-term protection against the virus. Very skeptical of these “bad news” vaccine reports When vaccinated, some are aware of in the first day or two Example of innate immune response: broke around the body The body’s inflammatory response aimed at quickly removing foreign molecules It varies from person to person, but how dramatic the initial response is is not necessarily related to the long-term response. With the two mRNA COVID-19 vaccines, more than 90% of immunized individuals developed a defensive adaptive immune response, less than 50% developed some side effects, and most were mild. The bottom line is that you can’t determine how well a vaccine works in your body based on what you can detect from the outside. The immune response to the vaccine varies from person to person, but the side effects after injection do not tell you which one you are. It is the second adaptive immune response that helps your body acquire vaccine immunity, not their early pain or the inflammatory response that causes pain. Anyway, what are the side effects? Side effects are the usual reaction to foreign body injections. They include fever, muscle aches, and injection site discomfort and are mediated by an innate immune response. Neutrophils or macrophages in the body become aware of vaccine molecules and produce cytokines (molecular signals that cause fever, chills, malaise, and muscle aches). .. Doctors expect this cytokine response to occur each time a foreign body is injected into the body. In a study in which neither the recipient nor the researchers knew which individuals were vaccinated with the mRNA or placebo, about half of people aged 16-55 years who received SARS received the CoV-2 vaccine for the second time. I developed headache after administration. Although this reaction may be vaccine-related, one-quarter of people who received only placebo also developed headaches. Therefore, for very common symptoms, it can be very difficult to reliably attribute them to the vaccine. Researchers anticipate some reports of side effects. Adverse events, on the other hand, are unexpected to the doctor as a result of the vaccine. It includes organ failure and serious damage to any part of the body. The blood clot that triggered the US to suspend the distribution of the Johnson & Johnson vaccine is a very rare event and appears to occur at a frequency of one in a million. Whether they are definitely caused by the vaccine is still under investigation, but if scientists conclude them, blood clots are a very rare side effect. Which component of the shot causes side effects? Pfizer and Moderna’s only “active ingredient” vaccine is an mRNA command that directs recipient cells to build viral proteins. However, the shot contains other ingredients that help the mRNA move through the body. In order for vaccine mRNA to enter the cells of a vaccinated person and do its job, it must evade enzymes in the body and destroy them naturally. Researchers protected the vaccine’s mRNA by wrapping it in a lipid foam to prevent destruction. Other components of the shot, such as polyethylene glycol that are part of this lipid envelope, can cause an allergic reaction. If you feel sick after a shot, does it indicate strong immunity? Scientists have not identified a link to the initial inflammatory response. Long-term response that leads to protection. There is no scientific evidence that people with more obvious side effects from the vaccine are better protected from COVID-19. And there is no reason why the exaggerated innate immune response makes your adaptive response even better. Both approved mRNA vaccines provided protective immunity to more than 90% of recipients, but less than 50% reported responses to the vaccine and far fewer responded severely, as detailed in The Daily Beast. Please refer to the. Get top stories in your inbox every day. Sign up now! 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