Pfizer has chosen a much lower dose of COVID-19 vaccine than Moderna to minimize side effects, its top scientists say.


Covid Vaccine Ian McKellan London.JPG

Actor Ian McKellen will receive the Pfizer-BioNTech COVID-19 vaccine in London on December 16th. Distribution via Jeff Moore / Reuters

  • Top Pfizer scientists said the company chose a relatively low vaccine dose to minimize side effects.

  • Pfizer’s vaccine contains 30 micrograms of mRNA, which is the active ingredient. Moderna’s has 100 micrograms.

  • According to the CDC, both vaccines cause similar side effects.

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Pfizer Leading scientists Company COVID-19 vaccine, Lower than the Moderna vaccine.

Pfizer’s COVID-19 vaccine contains 30 micrograms of mRNA, which is the active ingredient of the vaccine, and Moderna’s vaccine contains 100 micrograms.Scientists speculate that this may be the reason why Pfizer’s shots produced a lower antibody response than Modana’s shots. Recent research.

Pfizer’s Chief Scientific Officer, Philip Dormitzer Told the Financial Times On Wednesday, Pfizer and co-developer BioNTech said they “used a minimum dose level” that could provide a stronger immune response than simply catching COVID-19.

Dormitzer added that higher doses may be at risk of more side effects. Financial Times..

“Looking at what’s happening with all the COVID-19 vaccines out there, derailers are often an adverse event and it’s happening,” he said.

Pfizer and Modana COVID-19 vaccines cause similar side effects. Centers for Disease Control and Prevention.. The possible side effects are: Pain, pain, red arms. Myalgia; malaise; and fever.

A type of heart inflammation called myocarditis “Very rare” side effects Resolve both vaccines, and quickly.

There is a case report An angry red rash of the so-called “Moderna arm” that disappears spontaneously after taking a shot of Moderna, not seen in Pfizer. The insider asked Moderna for comment, but didn’t get an immediate response.

In the United States, Pfizer shots have been distributed over 214 million times and Modana shots have been distributed over 147 million times. According to the CDC.

Moderna Shot boosted higher antibodies than Pfizer

Published 1,600 Belgian Healthcare Workers Study As a JAMA research letter On August 30, Moderna’s COVID-19 vaccine was found to produce twice as much antibody as Pfizer 6-10 weeks after vaccination.

The authors of the study said that the higher mRNA levels of Modana’s vaccine compared to Pfizer and the longer intervals between Pfizer doses “may explain this difference.”

Another study from the University of Virginia JAMA Research Letter On September 2, Pfizer found that there was no difference in antibody response between age groups using Moderna’s vaccine, but Pfizer showed lower antibody response in people over 50 years of age. The researchers said that differences between vaccines could be “related” to the amount of mRNA in the vaccine.

The antibody response is only one aspect of the immune system, and the antibody levels required to protect it from COVID-19 have not yet been established.

Vaccine protection also depends on whether the antibody response changes over time. for example, Recent research from Oxford University Antibody levels from Pfizer shots decreased over time, and levels from AstraZeneca remained the same, indicating that the antibody levels of the Pfizer and AstraZeneca vaccines were the same at four months.

Previous real-world data After a single dose, Canadian researchers found that the Pfizer vaccine was 56% effective against COVID-19 and that the highly infectious delta mutant caused symptoms. Studies have shown that Moderna was 72% effective.

However, other factors may have influenced the outcome, such as Pfizer’s vaccine being usually given to older people who tend to have a weak immune response. This study has not been scrutinized by peer review experts.

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